400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
胶原蛋白三肽。棕榈酰化Gly-Pro-Hyp用作抗皱化妆品组合物的成分。促进胶原蛋白I的合成，修复肌肤
编号：110563
CAS号：2239-67-0/103192-50-3
单字母：H2N-GP-Hyp-OH
| 编号: | 110563 |
| 中文名称: | 三肽-29、Tripeptide-29、胶原蛋白三肽、Collagen tripeptide |
| 英文名: | Tripeptide-29、Collagen tripeptide |
| CAS号: | 2239-67-0，freebase 103192-50-3，醋酸盐 |
| 单字母: | H2N-GP-Hyp-OH |
| 三字母: | H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -Gly甘氨酸：glycine。系统命名为 2-氨基乙酸。是编码氨基酸中没有旋光性的最简单的氨基酸，因具有甜味而得名。符号：G，Gly。 -ProL-脯氨酸：proline。系统命名为吡咯烷-(2S)-羧酸。为亚氨基酸。是编码氨基酸。在肽链中有特殊作用，如易形成顺式的肽键等。符号：P，Pro。 -Hyp羟脯氨酸：hydroxyproline。系统命名为 3-羟基脯氨酸（3Hyp）或 4-羟基脯氨酸（4Hyp）。是从脯氨酸衍生而来的一种亚氨基酸。胶原中约 50%的脯氨酸被羟基化成为4Hyp和少量 3Hyp。Hyp也存在于弹性蛋白、牙齿珐琅和伸展蛋白中。符号：HyPro，HyP。反式-4-羟基-L-脯氨酸（Hyp）是脯氨酸的一种羟基化变体。虽然Hyp不是天然编码的，但它存在于多种哺乳动物蛋白质（如胶原蛋白、弹性蛋白和argonaute 2）以及植物蛋白质（如植物细胞壁中的糖蛋白（HRGPs））中。 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 3 |
| 分子式: | C12H19N3O5 |
| 平均分子量: | 285.3 |
| 精确分子量: | 285.13 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 0.97 |
| 平均亲水性: | - |
| 疏水性值: | -1 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 氨基酸衍生物肽 三肽 |
胶原蛋白三肽。棕榈酰化Gly-Pro-Hyp用作抗皱化妆品组合物的成分。
Collagen tripeptide. Palmitoylated Gly-Pro-Hyp is used as ingredient in anti-wrinkle cosmetic compositions.
二肽基肽酶IV（DPP IV）的抑制剂
Inhibitors of Dipeptidyl-Peptidase IV (DPP IV)
X-Pro氨基肽酶底物
Substrates of X-Pro Aminopeptidase
H-Gly-Pro-Hyp-OH is a collagen gel that is extracted from bovine skin. Collagen gel is a dietary supplement that can be applied to wounds and burns to promote healing. Collagen gel contains the amino acids glycine, proline, hydroxyproline, and hypochlorous acid. It also has an anti-inflammatory cytokine called IL-10. Hydrogen bonds form between the amino acids in collagen gel to give it its strength and stability. The LC-MS/MS method was used to identify the sequences of this peptide in order to confirm its identity. Collagen gel is neutral at pH 7 and has no effect on cellular function at this pH. The carboxy terminal of collagen gel is trifluoroacetic acid which can cause liver cells to die when ingested orally or intravenously due to its toxicity.
| DOI | 名称 | |
|---|---|---|
| 10.3109/09637480903257711 | Hydroxyproline-containing dipeptides and tripeptides quantified at high concentration in human blood after oral administration of gelatin hydrolysate | 下载 |
| 10.3109/14756366.2013.858143 | Inhibitory effect of collagen-derived tripeptides on dipeptidylpeptidase-IV activity | 下载 |
| 10.1021/jf5039597 | Highly accurate quantification of hydroxyproline-containing peptides in blood using a protease digest of stable isotope-labeled collagen | 下载 |
| 10.1080/09168451.2015.1062711 | Absorption and plasma kinetics of collagen tripeptide after peroral or intraperitoneal administration in rats | 下载 |
| 10.1021/acs.jafc.6b00609 | Efficient Absorption of X-Hydroxyproline (Hyp)-Gly after Oral Administration of a Novel Gelatin Hydrolysate Prepared Using Ginger Protease | 下载 |
