400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
| 编号: | 190010 |
| 中文名称: | 标记肽BZ-Tyr-对硝基苯胺 |
| 英文名: | BZ-Tyr-pNA |
| CAS号: | 6154-45-6 |
| 单字母: | Bz-Y-pNA |
| 三字母: | Benzoyl 苯甲酰基（Bz，C6H5CO-）是醇的芳酰基保护基团，在稀碱性溶液中可通过水解轻易去除。 -TyrL-酪氨酸：tyrosine。系统命名为(2S)-氨基-3-(4-羟基苯基)丙酸。是编码氨基酸。符号：Y，Tyr。 -pNA对硝基苯胺 |
| 氨基酸个数: | 1 |
| 分子式: | C22H19O5N3 |
| 平均分子量: | 405.4 |
| 精确分子量: | 405.13 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 1 |
| 平均亲水性: | -3.4 |
| 疏水性值: | -0.9 |
| 消光系数: | 1490 |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 酪氨酸类 |
Bz-Tyr-pNA is a peptide that has been shown to inhibit the activity of serine proteases. The peptide consists of Boc-Tyr-Nal-pNA, which is an artificial amino acid that has been synthesized for use as a substrate in assays and as a probe in the study of protein structure and function. Bz-Tyr-pNA inhibits the enzyme activity of a recombinant human neutrophil elastase, with an IC50 of about 12.5 μM. This peptide also inhibits the catalytic action of human neutrophil elastase by binding to its active site and blocking access to the substrate Tyr-pNA. It has been shown that Bz-Tyr-pNA can be used as an immunosuppressant to prevent graft rejection, although it is not yet approved for this use.
