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| 编号: | 569951 |
| 中文名称: | 5FAM-Lys-Gly-Tyr-Tyr-OH |
| 单字母: | 5FAM-KGYY-OH |
| 三字母: | 5FAM N端标记5-FAM,5-羧基荧光素(5FAM)是一种荧光染料,其激发波长为492纳米,发射波长为517纳米。在荧光共振能量转移(FRET)实验中,像FAM和5FAM这样的供体通常与受体(CPQ2)配对使用。 -LysL-赖氨酸:lysine。系统命名为(2S)-6-二氨基已酸。是编码氨基酸中的碱性氨基酸,哺乳动物的必需氨基酸。在蛋白质中的赖氨酸可以被修饰为多种形式的衍生物。符号:K,Lys。 -Gly甘氨酸:glycine。系统命名为 2-氨基乙酸。是编码氨基酸中没有旋光性的最简单的氨基酸,因具有甜味而得名。符号:G,Gly。 -TyrL-酪氨酸:tyrosine。系统命名为(2S)-氨基-3-(4-羟基苯基)丙酸。是编码氨基酸。符号:Y,Tyr。 -TyrL-酪氨酸:tyrosine。系统命名为(2S)-氨基-3-(4-羟基苯基)丙酸。是编码氨基酸。符号:Y,Tyr。 -OHC端羧基:C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时,通常将C端放在肽链的右边。 |
| 氨基酸个数: | 4 |
| 分子式: | C47H45O13N5 |
| 平均分子量: | 887.89 |
| 精确分子量: | 887.3 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 3 |
| 平均亲水性: | -1.2666666666667 |
| 疏水性值: | -1.53 |
| 消光系数: | 2980 |
| 来源: | 人工化学合成,仅限科学研究使用,不得用于人体。 |
| 纯度: | 95% 或98%可选 |
| 盐体系: | 若定制,可选TFA盐、醋酸盐、盐酸盐和柠檬酸盐等 |
| 生成周期: | 现货或定制2-3周,请咨询销售人员 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | FAM标记肽 |
Peptide 5Fam-KGYY-OH is a Research Peptide with significant interest within the field academic and medical research. Recent citations using 5Fam-KGYY-OH include the following: Incorporating Specific Biological Functionality into Self-Assembling Peptide Amphiphiles for Nanostructured Biomaterials S Khan - 2012 - search.proquest.comhttps://search.proquest.com/openview/7f608cbcc479dfb1745dda6cbe29fa06/1?pq-origsite=gscholar&cbl=18750 Orientational ordering of carotenoids in myelin membranes resolved by polarized Raman microspectroscopy NP Kutuzov , AR Brazhe , GV Maksimov, OE Dracheva - Biophysical , 2014 - cell.comhttps://www.cell.com/biophysj/pdf/S0006-3495(14)00714-0.pdf Small-molecule inhibitors of the CD40-CD40L costimulatory protein-protein interaction J Chen, Y Song , D Bojadzic - Journal of medicinal , 2017 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.7b01154 CD40-targeted peptide proposed for type 1 diabetes therapy lacks relevant binding affinity to its cognate receptor. Reply to Pagni PP, Wolf A, Lo Conte M et al GM Vaitaitis, MH Olmstead, DM Waid, JR Carter - Diabetologia, 2019 - Springerhttps://link.springer.com/article/10.1007/s00125-019-4945-7 A CD40-targeted peptide controls and reverses type 1 diabetes in NOD mice GM Vaitaitis, MH Olmstead, DM Waid, JR Carter - Diabetologia, 2014 - Springerhttps://link.springer.com/article/10.1007/s00125-014-3342-5 A CD40 targeting peptide prevents severe symptoms in experimental autoimmune encephalomyelitis GM Vaitaitis, MG Yussman, DH Wagner Jr - Journal of neuroimmunology, 2019 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0165572819300633 Modulating CD40 and integrin signaling in the proinflammatory nexus using a 15-amino-acid peptide, KGYY15 GM Vaitaitis, DH Wagner - Journal of Biological Chemistry, 2023 - ASBMBhttps://www.jbc.org/article/S0021-9258(23)00267-3/abstract Importance of CD40/CD40L dyad in the course of infection with Trypanosoma cruzi: Impact of its inhibition FM Frank, DH Wagner Jr, M Postan, PB Petray - Microbial Pathogenesis, 2023 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0882401023003601 Targeting type 1 diabetes: selective approaches for new therapies DF Sheehy, SP Quinnell, AJ Vegas - Biochemistry, 2019 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.biochem.8b01118 CD40-targeting KGYY15 peptides do not efficiently block the CD40-CD40L interaction D Bojadzic, P Buchwald - Diabetologia, 2019 - Springerhttps://link.springer.com/article/10.1007/s00125-019-04996-6
FAM标记说明:
Carboxyfluorescein (FAM) is fluorophor with an excitation at 492 nm ▉ and emission of 517 nm ▉. Donors like FAM and 5FAM are often paired together with acceptors (CPQ2) for FRET experiments.

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