133551-97-0_Big Endothelin-3 (1-41) amide (human)_Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-Ile-Asn-Thr-Pro-Glu-Gln-Thr-Val-Pro-Tyr-Gly-Leu-Ser-Asn-Tyr-Arg-Gly-Ser-Phe-Arg-NH2 (Disulfide bonds between Cys¹ and Cys¹⁵/Cys³ and Cys¹¹)_大内皮素(Big Endothelin)

Big Endothelin-3 (1-41) amide (human)
尽管与Big ET-1相比，人类大内皮素3的动脉压升高，但功效和功效却有所降低。

编号：114169

CAS号：133551-97-0

单字母：

编号:	114169
中文名称:	Big Endothelin-3 (1-41) amide (human)
英文名:	Big Endothelin-3 (1-41) amide (human)
CAS号:	133551-97-0
三字母:	Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-Ile-Asn-Thr-Pro-Glu-Gln-Thr-Val-Pro-Tyr-Gly-Leu-Ser-Asn-Tyr-Arg-Gly-Ser-Phe-Arg-NH2 (Disulfide bonds between Cys¹ and Cys¹⁵/Cys³ and Cys¹¹)
来源:	人工化学合成，仅限科学研究使用，不得用于人体。
储存条件:	负80℃至负20℃
标签:	大内皮素(Big Endothelin)

Human big endothelin-3 increased arterial pressure, although with less potency and efficacy compared with Big ET-1.

Big Endothelin-3 (Human, 1-41 Amide) is a precursor molecule of the Endothelin-3 (ET-3) peptide, that belongs to the large family of endothelin peptides which activate the G-protein coupled receptors ETA and ETB. However ET-3 has lower affinity for the ETA receptors compared to Endothelin-1 (ET-1) and Endothelin-2 (ET-2), whereas all three endothelins have similar affinity for ETB receptors. As ETB receptors make up around 90% of the endothelin receptors found in the cerebral cortex in humans, ET-3 can be nicknamed the ‘brain endothelin’. Also through ET-3’s activation of ETB receptors, ET-3 is involved in the development of the enteric nervous system which controls within the gut, blood flow, secretion and intestinal motility. This product has disulfide bonds between Cys1-Cys15 and Cys3-Cys11.
D.M.Pollock et al., Eur. J. Pharmacol., 231, 459 (1993)
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