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一种从血液中释放的前肽衍生的天然肽,能够阻断 TREK-1 (KCNK2 或 K2P2.1) 通道的活性。
编号:200484
CAS号:1270083-24-3
单字母:H2N-YAPLPRWSGPIGVSWGLR-OH
Spadin 是一种从血液中释放的前肽衍生的天然肽,能够阻断 TREK-1 (KCNK2 或 K2P2.1) 通道的活性。Spadin 与 TREK-1 特异性结合,亲和力为 10 nM。Spadin 是一种有效的抗抑郁药。
Spadin, a natural peptide derived from a propeptide released in blood, is able to block the TREK-1 (KCNK2 or K2P2.1) channel activity. Spadin binds specifically to TREK-1 with an affinity of 10 nM. Spadin is an efficient antidepressant in mice[1].
Jean Mazella, et al.Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 2010 Apr 13;8(4):e1000355. : https://pubmed.ncbi.nlm.nih.gov/20405001/