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Ile34-β- 淀粉样蛋白(25-34)引入疏水取代,调控易聚集核心内的堆积相互作用。广泛用于研究 β- 折叠排列与自组装机制,为探究疏水效应对多肽聚集的影响提供明确模型。主要用于结构生物物理与淀粉样蛋白研究。
编号:636035
CAS号:
单字母:H2N-VGGVVIATVI-OH
Ile34-β- 淀粉样蛋白(25-34)引入疏水取代,调控易聚集核心内的堆积相互作用。广泛用于研究 β- 折叠排列与自组装机制,为探究疏水效应对多肽聚集的影响提供明确模型。主要用于结构生物物理与淀粉样蛋白研究。
Beta-Amyloid (36-45) extends the C-terminal domain with residues that promote aggregation and structural compaction. Its sequence provides a platform for analyzing hydrophobic clustering and peptide-driven self-organization. Folding behavior shifts under different solvent conditions, enabling detailed mechanistic studies. Applications include biophysical characterization, fibril modeling, and sequence-function exploration.





