这是一个突变的β-淀粉样蛋白1-28个氨基酸的序列，其中KLVFF序列（Ab16-20）被AAVFA取代
编号：434174
CAS号：
单字母：H2N-DAEFRHDSGYEVHHQAAVFAAEDVGSNK-OH
这是一个突变的β-淀粉样蛋白1-28个氨基酸的序列，其中KLVFF序列（Ab16-20）被AAVFA取代。KLVFF是最短的肽，对全长Aβ显示出一致的高结合能力。第一、第二和第五个残基（即KLXXF）对于结合是关键的。该Aβ（1-28）氨基酸序列在16-20区的取代严重损害了肽聚集和形成淀粉样原纤维的能力。
This is a mutated β-Amyloid 1 to 28 amino acids sequence in which the KLVFF sequence (Ab16-20) is substituted with AAVFA. The KLVFF is the shortest peptide displaying consistent high binding capacity to full-length Aβ. The first, second, and fifth residues (i.e. KLXXF) are critical for binding. The substitutions in this Aβ (1-28) amino acids sequence in the 16 to 20 region profoundly impair the ability of the peptide to aggregate and form amyloid-like fibrils.
Tjernberg, L. et al. J. Biol. Chem. 271, 8545 (1996).
![淀粉肽[Ala16,17,20]-β-Amyloid (1-28)、DAEFRHDSGYEVHHQAAVFAAEDVGSNK、Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Ala-Ala-Val-Phe-Ala-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys,杭州专肽生物的产品](/static/ah/images/def.jpg)
