Most circulating ghrelin is des-octanoyl ghrelin. The non-acylated ghrelin was considered inactive at first, though biological activities such as stimulation of adipogenesis and control of cell growth could be demonstrated more recently. Both ghrelin and
编号：185813
CAS号：313951-59-6
单字母：H2N-GSSFLSPEHQRVQQRKESKKPPAKLQPR-OH
| 编号: | 185813 |
| 中文名称: | (Des-octanoyl)-Ghrelin(human) |
| 英文名: | (Des-octanoyl)-Ghrelin(human) |
| CAS号: | 313951-59-6 |
| 单字母: | H2N-GSSFLSPEHQRVQQRKESKKPPAKLQPR-OH |
| 三字母: | H2N N端氨基 -Gly甘氨酸 -Ser丝氨酸 -Ser丝氨酸 -Phe苯丙氨酸 -Leu亮氨酸 -Ser丝氨酸 -Pro脯氨酸 -Glu谷氨酸 -His组氨酸 -Gln谷氨酰胺 -Arg精氨酸 -Val缬氨酸 -Gln谷氨酰胺 -Gln谷氨酰胺 -Arg精氨酸 -Lys赖氨酸 -Glu谷氨酸 -Ser丝氨酸 -Lys赖氨酸 -Lys赖氨酸 -Pro脯氨酸 -Pro脯氨酸 -Ala丙氨酸 -Lys赖氨酸 -Leu亮氨酸 -Gln谷氨酰胺 -Pro脯氨酸 -Arg精氨酸 -OHC端羧基 |
| 氨基酸个数: | 28 |
| 分子式: | C141H235N47O41 |
| 平均分子量: | 3244.66 |
| 精确分子量: | 3242.77 |
| 等电点(PI): | 12.29 |
| pH=7.0时的净电荷数: | 6.21 |
| 平均亲水性: | 0.88695652173913 |
| 疏水性值: | -1.68 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 未分类肽 |
Most circulating ghrelin is des-octanoyl ghrelin. The non-acylated ghrelin was considered inactive at first, though biological activities such as stimulation of adipogenesis and control of cell growth could be demonstrated more recently. Both ghrelin and the more abundant endogenous form des-octanoyl ghrelin could play a role in the paracrine regulation of vascular tone in humans.
| DOI | 名称 | |
|---|---|---|
| 10.1007/BF03345156 | Non-acylated ghrelin does not possess the pituitaric and pancreatic endocrine activity of acylated ghrelin in humans | 下载 |
| 10.1016/j.cardiores.2005.09.001 | Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man | 下载 |
| 10.1016/j.jpba.2008.01.033 | Evaluation of saliva collection devices for the analysis of steroids, peptides and therapeutic drugs | 下载 |
| 10.4155/bio.12.248 | Prandial ghrelin attenuation provides evidence that des-acyl ghrelin may be an artifact of sample handling in human plasma | 下载 |
