Dec-RVKR-CMK binds to the catalytic site of furin and therefore acts as a potent inhibitor of cleavage and fusion activity of viral glycoproteins, as well as virus replication. Furthermore it was demonstrated that Dec-RVKR-CMK decreased the production of
编号：113563
CAS号：150113-99-8
单字母：Decanoicacid-RVKR-CMK
| 编号: | 113563 |
| 中文名称: | 四肽Decanoyl-Arg-Val-Lys-Arg-chloromethylketon |
| 英文名: | Decanoyl-Arg-Val-Lys-Arg-chloromethylketon |
| CAS号: | 150113-99-8 |
| 单字母: | Decanoicacid-RVKR-CMK |
| 三字母: | Decanoicacid 癸酸修饰、癸酰化 -Arg精氨酸 -Val缬氨酸 -Lys赖氨酸 -Arg精氨酸 -CMKC端氯甲基酮修饰 |
| 氨基酸个数: | 4 |
| 分子式: | C34H66O6N11l1 |
| 平均分子量: | 724.96 |
| 精确分子量: | 724.52 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 3 |
| 平均亲水性: | 1.875 |
| 疏水性值: | -2.18 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl |
| 储存条件: | 负80℃至负20℃ |
| 标签: | CMK(氯甲基酮)修饰 |
Dec-RVKR-CMK binds to the catalytic site of furin and therefore acts as a potent inhibitor of cleavage and fusion activity of viral glycoproteins, as well as virus replication. Furthermore it was demonstrated that Dec-RVKR-CMK decreased the production of β-amyloid-induced active matrix metalloproteinase 2 in U87 cells. Apart from furin, Dec-RVKR-CMK also inhibited the proprotein convertases PC7/LPC, PACE4, and PC6 (W.Garten, personal communication).
| DOI | 名称 | |
|---|---|---|
| 10.1038/360358a0 | Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160 | 下载 |
| 10.1016/0042-6822(89)90103-7 | Inhibition of proteolytic activation of influenza virus hemagglutinin by specific peptidyl chloroalkyl ketones | 下载 |
