受精促进肽 (FPP) 是一种 TRH 类似物，以前从兔前列腺和人类精液中纯化和表征。已显示该肽的纳摩尔浓度可增强小鼠附睾精子的获能，同时增加受精能力。它也在甲状腺中检测到。根据 Nguyen 等人的一项研究。Pyr-Glu-Pro-NH 2 对抗 TRH 在哺乳动物中枢神经系统中的胆碱能作用：与大鼠海马中等量的 TRH 共同灌注导致 TRH 诱导的乙酰胆碱释放显着减弱。
编号：147114
CAS号：85541-78-2
单字母：Pyr-EP-NH2
| 编号: | 147114 |
| 中文名称: | 受精促进肽Pyr-Glu-Pro-NH2 |
| 英文名: | Pyr-Glu-Pro-NH2 |
| CAS号: | 85541-78-2 |
| 单字母: | Pyr-EP-NH2 |
| 三字母: | Pyr 焦谷氨酸 -Glu谷氨酸 -Pro脯氨酸 -NH2C端酰胺化 |
| 氨基酸个数: | 2 |
| 分子式: | C15H22N4O6 |
| 平均分子量: | 354.36 |
| 精确分子量: | 354.15 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | -1 |
| 酸性基团个数: | pH=7.0时的净电荷数：-1.00 |
| 碱性基团个数: | 平均亲水性：非常亲水 |
| 平均亲水性: | 3 |
| 疏水性值: | -2.55 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 二肽(Dipeptide) 促甲状腺激素释放激素 |
受精促进肽 (FPP) 是一种 TRH 类似物，以前从兔前列腺和人类精液中纯化和表征。已显示该肽的纳摩尔浓度可增强小鼠附睾精子的获能，同时增加受精能力。它也在甲状腺中检测到。根据 Nguyen 等人的一项研究。Pyr-Glu-Pro-NH 2 对抗 TRH 在哺乳动物中枢神经系统中的胆碱能作用：与大鼠海马中等量的 TRH 共同灌注导致 TRH 诱导的乙酰胆碱释放显着减弱。
Fertilization-promoting peptide (FPP), a TRH analog, was previously purified and characterized from both rabbit prostate and human semen. Nanomolar concentrations of this peptide have been shown to enhance capacitation of mouse epididymal spermatozoa with a concomitant increase in fertilizing ability. It was also detected in the thyroid gland. According to a study of Nguyen et al. Pyr-Glu-Pro-NH₂ opposes the cholinergic effect of TRH in the mammalian CNS: Co-perfusion with an equivalent of TRH in the rat hippocampus resulted in a significant attenuation of TRH-induced acetylcholine release.
甲状旁腺激素（PTH），又称为甲状旁腺激素或甲状旁腺，是由甲状旁腺主细胞分泌的含有84个氨基酸的多肽。它的作用是增加血液中钙的浓度，PTH通过作用于甲状旁腺激素1受体和甲状旁腺激素2受体，增加血液中的钙浓度(1)。 PTH降低肾脏的近端小管磷酸盐的再吸收，这意味着更多的磷酸盐通过尿排出体外。PTH增加从肠道和骨头吸收进入血液的磷酸盐含量(2)。在骨中，从破碎的骨中释放的钙的含量比磷酸盐稍多。在肠内，活性维生素D增加，介导钙和磷的吸收。
1. Bieglmayer C, Prager G, Niederle B (October 2002). "Kinetic analyses of parathyroid hormone clearance as measured by three rapid immunoassays during parathyroidectomy". Clin. Chem. 48 (10): 1731–8.
2. PooleK, Reeve J (2005). "Parathyroid hormone - a bone anabolic and catabolic agent". Curr Opin Pharmacol 5 (6): 612–7.
| DOI | 名称 | |
|---|---|---|
| 10.1016/s0960-894x(03)00081-7 | Prodrugs to enhance central nervous system effects of the TRH-like peptide pGlu-Glu-Pro-NH2 | 下载 |
| 10.1016/j.ica.2004.11.045 | Binding of copper(II) to thyrotropin-releasing hormone (TRH) and its analogs | 下载 |
| 10.1016/j.neulet.2006.12.039 | Evidence for interplay between thyrotropin-releasing hormone (TRH) and its structural analogue pGlu-Glu-Pro-NH2 ([Glu2]TRH) in the brain: an in vivo microdialysis study | 下载 |
| 10.1016/0925-4439(94)90107-4 | Peptides related to thyrotrophin-releasing hormone (TRH) in human prostate and semen | 下载 |
| 10.1016/0196-9781(94)90154-6 | Identification of the human seminal TRH-like peptide pGlu-Phe-Pro-NH2 in normal human prostate | 下载 |
| 10.1677/joe.0.1420111 | The effects of pyroglutamylglutamylprolineamide, a peptide related to thyrotrophin-releasing hormone, on rat anterior pituitary cells in culture | 下载 |
| 10.1002/mrd.1080380213 | Stimulating effect of pyroglutamylglutamylprolineamide, a prostatic, TRH-related tripeptide, on mouse sperm capacitation and fertilizing ability in vitro | 下载 |
| 10.1016/s0014-2999(98)00593-7 | The thyrotropin-releasing hormone-like peptides pGlu-Phe-Pro amide and pGlu-Glu-Pro amide increase plasma triiodothyronine levels in the mouse; the activity is sensitive to testosterone | 下载 |
