用于测定胶原酶活性的底物。Dnp-PQGIAGQR 的裂解产生 Dnp-PQG,M-1335。
编号:200089
CAS号:63014-08-4/61714-08-4
单字母:Dnp-PQGIAGQr-OH
编号: | 200089 |
中文名称: | 八肽Dnp-PQGIAGQ-DArg |
CAS号: | 63014-08-4/61714-08-4 |
单字母: | Dnp-PQGIAGQr-OH |
三字母: | Dnp 暂无说明 -Pro脯氨酸 -Gln谷氨酰胺 -Gly甘氨酸 -Ile异亮氨酸 -Ala丙氨酸 -Gly甘氨酸 -Gln谷氨酰胺 -DArgD型精氨酸 -OHC端羧基 |
氨基酸个数: | 8 |
分子式: | C40H61N15O15 |
平均分子量: | 992 |
精确分子量: | 991.45 |
等电点(PI): | - |
pH=7.0时的净电荷数: | 1 |
平均亲水性: | 0.22 |
疏水性值: | -0.95 |
消光系数: | - |
来源: | 人工化学合成,仅限科学研究使用,不得用于人体。 |
储存条件: | 负80℃至负20℃ |
标签: | D型氨基酸肽 炎症研究 |
Substrate for the assay of collagenase activity. Cleavage of Dnp-PQGIAGQR yields Dnp-PQG, M-1335.
很多蛋白在细胞中非常容易被降解,或被标记,进而被选择性地破坏。但含有部分D型氨基酸的多肽则显示了很强的抵抗蛋白酶降解能力。
DOI | 名称 | |
---|---|---|
10.1023/b:mcbi.0000012838.41792.d2 | Identification, purification and characterization of matrix metalloproteinase-2 in bovine pulmonary artery smooth muscle plasma membrane | 下载 |
10.1016/0006-2944(77)90026-6 | Synthetic substrates for vertebrate collagenase | 下载 |
10.1155/2013/329740 | 4-methoxycarbonyl curcumin: a unique inhibitor of both inflammatory mediators and periodontal inflammation | 下载 |
10.1093/oxfordjournals.jbchem.a132804 | The existing forms of collagenase in the human uterine cervix | 下载 |
10.1016/0006-291x(81)91582-5 | Metal binding peptide inhibitors of vertebrate collagenase | 下载 |
10.1016/0003-2697(82)90355-4 | Characterization of vertebrate collagenase activity by high-performance liquid chromatography using a synthetic substrate | 下载 |
10.1111/j.1432-1033.1983.tb07541.x | Proteinases in human polymorphonuclear leukocytes. Purification and characterization of an enzyme which cleaves denatured collagen and a synthetic peptide with a Gly-Ile sequence | 下载 |
10.1016/0005-2744(79)90263-8 | Purification of tadpole collagenase and characterization using collagen and synthetic substrates | 下载 |