大鼠和小鼠中的强效 LHRH 类似物。Alarelin 可逆地延迟大鼠的性成熟。作为单一药物或与多巴胺受体拮抗剂联合应用，如多潘立酮，用于刺激和同步排卵和鱼类养殖产卵。CAS 编号（净值）：79561-22-1。
编号：200202
CAS号：267878-61-5
单字母：Pyr-HWYlLRP-NHEt
| 编号: | 200202 |
| 中文名称: | 七肽pGlu-HWY-DLeu-LRP-NHEt |
| CAS号: | 267878-61-5 |
| 单字母: | Pyr-HWYlLRP-NHEt |
| 三字母: | Pyr 焦谷氨酸 -His组氨酸 -Trp色氨酸 -Tyr酪氨酸 -DLeuD型亮氨酸 -Leu亮氨酸 -Arg精氨酸 -Pro脯氨酸 -NHEtC端乙胺基化修饰 |
| 氨基酸个数: | 7 |
| 分子式: | C56H79N14O10 |
| 平均分子量: | 1108.31 |
| 精确分子量: | 1107.61 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 2.24 |
| 平均亲水性: | -1.3166666666667 |
| 疏水性值: | -0.5 |
| 消光系数: | 6990 |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | D型氨基酸肽 垂体和下丘脑激素 |
Potent LHRH analog in rats and mice. Alarelin reversibly delays sexual maturation in rats.Applied as single drug or in combination with a dopamin receptor antagonist as domperidone for the stimulation and synchronization of ovulation and spawning in fish farming. CAS Number (net): 79561-22-1.
很多蛋白在细胞中非常容易被降解，或被标记，进而被选择性地破坏。但含有部分D型氨基酸的多肽则显示了很强的抵抗蛋白酶降解能力。
| DOI | 名称 | |
|---|---|---|
| 10.1016/s0014-827x(02)01295-8 | Sustained release and biological availability of dalarelin from the biodegradable coacervate microcapsules | 下载 |
| 10.1210/en.2004-0558 | Novel expression of gonadotropin subunit genes in oocytes of the gilthead seabream (Sparus aurata) | 下载 |
| 10.1002/jms.1416 | In vivo evaluation and in vitro metabolism of leuprolide in mice--mass spectrometry-based biomarker measurement for efficacy and toxicity | 下载 |
| 10.1016/j.cbpa.2010.11.016 | Effects of in vivo treatment with the dopamine antagonist pimozide and gonadotropin-releasing hormone agonist (GnRHa) on the reproductive axis of Senegalese sole (Solea senegalensis) | 下载 |
| 10.1016/j.ygcen.2011.10.013 | Dopamine control of LH release in the tench (Tinca tinca) | 下载 |
| 10.1016/j.ygcen.2013.06.005 | Chronic kisspeptin administration stimulated gonadal development in pre-pubertal male yellowtail kingfish (Seriola lalandi; Perciformes) during the breeding and non-breeding season | 下载 |
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| 10.1095/biolreprod32.2.226 | D-Ala6-des-Gly10-gonadotropin-releasing hormone ethylamide: absence of binding sites and lack of a direct effect in rabbit corpora lutea | 下载 |
| 10.1210/endo-100-4-918 | Insensitivity of bonnet monkeys to (D-Ala6, Des-Gly10) LHRH ethylamide, a potent new luteinizing hormone releasing hormone analogue in rats and mice | 下载 |
| 10.3748/wjg.v10.i12.1780 | Expression of gonadotropin-releasing hormone receptor and effect of gonadotropin-releasing hormone analogue on proliferation of cultured gastric smooth muscle cells of rats | 下载 |
| 10.1186/1477-7827-8-36 | Hormonal induction of spawning in 4 species of frogs by coinjection with a gonadotropin-releasing hormone agonist and a dopamine antagonist | 下载 |
| 10.1016/0303-7207(84)90153-9 | Androgen and progestogen production by prepubertal rat interstitial cells: study of the effects of LHRH and its analogues and their interactions with LH | 下载 |
| 10.1139/y84-141 | Chronic treatment with [D-Ala6, des Gly-NH2(10)]-LHRH ethylamide reversibly delays puberty in the female rat | 下载 |
| 10.1111/j.1399-3011.1998.tb01475.x | Interaction of gonadotropin-releasing hormone and its agonist analogs with Ca2+ in a nonpolar milieu. Correlation with biopotencies | 下载 |
| 10.1095/biolreprod59.5.1153 | Effects of long-term testosterone, gonadotropin-releasing hormone agonist, and pimozide treatments on gonadotropin II levels and ovarian development in juvenile female striped bass (Morone saxatilis) | 下载 |
