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72629-64-2,促黑素 γ₃-MSH,H2N-Tyr-Val-Met-Gly-His-Phe-Arg-Trp-Asp-Arg-Phe-Gly-Arg-Arg-Asn-Gly-Ser-Ser-Ser-Ser-Gly-Val-Gly-Gly-Ala-Ala-Gln-COOH,H2N-YVMGHFRWDRFGRRNGSSSSGVGGAAQ-OH,杭州专肽生物的产品

促黑素 γ₃-MSH

γ2-MSH 位于牛垂体中间叶的 ACTH/β-促脂素前体蛋白的隐蔽区域。

编号:200258

CAS号:72629-64-2

单字母:H2N-YVMGHFRWDRFGRRNGSSSSGVGGAAQ-OH

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  • 编号:200258
    中文名称:促黑素 γ₃-MSH
    CAS号:72629-64-2
    单字母:H2N-YVMGHFRWDRFGRRNGSSSSGVGGAAQ-OH
    三字母:H2N

    N端氨基

    -Tyr

    酪氨酸

    -Val

    缬氨酸

    -Met

    甲硫氨酸

    -Gly

    甘氨酸

    -His

    组氨酸

    -Phe

    苯丙氨酸

    -Arg

    精氨酸

    -Trp

    色氨酸

    -Asp

    天冬氨酸

    -Arg

    精氨酸

    -Phe

    苯丙氨酸

    -Gly

    甘氨酸

    -Arg

    精氨酸

    -Arg

    精氨酸

    -Asn

    天冬酰胺

    -Gly

    甘氨酸

    -Ser

    丝氨酸

    -Ser

    丝氨酸

    -Ser

    丝氨酸

    -Ser

    丝氨酸

    -Gly

    甘氨酸

    -Val

    缬氨酸

    -Gly

    甘氨酸

    -Gly

    甘氨酸

    -Ala

    丙氨酸

    -Ala

    丙氨酸

    -Gln

    谷氨酰胺

    -OH

    C端羧基

    氨基酸个数:27
    分子式:C126H188N44O37S1
    平均分子量:2943.18
    精确分子量:2941.39
    等电点(PI):12.98
    pH=7.0时的净电荷数:5.21
    平均亲水性:-0.047619047619048
    疏水性值:-0.73
    消光系数:6990
    来源:人工化学合成,仅限科学研究使用,不得用于人体。
    储存条件:负80℃至负20℃
    标签:垂体和下丘脑激素   

  • γ₂-MSH has been located in the cryptic region of the ACTH/β-lipotropin precursor protein from the intermediate lobe of bovine pituitary.

  • DOI名称
    10.1016/s0014-5793(03)00402-2gamma-MSH increases intracellular cAMP accumulation and GnRH release in vitro and LH release in vivo下载
    10.1021/bi0600300Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist下载
    10.1016/j.pbb.2006.08.001The differential influences of melanocortins on nociception in the formalin and tail flick tests下载
    10.1186/1471-2350-10-25Prevalence of pathogenetic MC4R mutations in Italian children with early onset obesity, tall stature and familial history of obesity下载
    10.1016/j.peptides.2010.08.025γ₂-Melanocyte stimulation hormone (γ₂-MSH) truncation studies results in the cautionary note that γ₂-MSH is not selective for the mouse MC3R over the mouse MC5R下载
    10.1038/278423a0Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor下载
    10.1016/0024-3205(79)90481-8Synthesis and biological activity of four gamma-melanotropin peptides derived from the cryuptic region of the adrenocorticotropin/beta-lipotropin precursor下载
    10.1161/01.hyp.7.3_pt_2.i145Sympathetic nervous system mediation of acute cardiovascular actions of gamma 2-melanocyte-stimulating hormone下载
    10.1210/endo-116-3-1227Gamma-2MSH is natriuretic in the rat下载
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