| 编号: | 200441 |
| 中文名称: | 二肽Z-Leu-Gly |
| CAS号: | 2706-38-9 |
| 单字母: | Z-LG-OH |
| 三字母: | Cbz N端Cbz保护 -Leu亮氨酸 -Gly甘氨酸 -OHC端羧基 |
| 氨基酸个数: | 2 |
| 分子式: | C16H22O5N2 |
| 平均分子量: | 322.36 |
| 精确分子量: | 322.15 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | - |
| 平均亲水性: | -1.8 |
| 疏水性值: | 1.7 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | CBZ修饰肽 二肽(Dipeptide) |
Z-LRGG-AMC is a fluorogenic substrate for isopeptidase T (IPaseT) and other ubiquitin C-terminal hydrolases (UCHs) based on the C-termini of ubiquitin with a kcat/Km value of 18 M⁻¹s⁻¹. Together with our product I-1690 it forms the basis of continuous assays for precise mechanistic studies or microtiter plate assays for high-throughput inhibitor screening. LRGG is the preferred substrate sequence of the human deSUMOylating enzymes SENP6 and 7. Stock solutions of Boc-LRGG-AMC are best prepared in DMSO.
| DOI | 名称 | |
|---|---|---|
| 10.1042/BJ20070940 | Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family | 下载 |
| 10.1021/bi00039a017 | Kinetic studies of isopeptidase T: modulation of peptidase activity by ubiquitin | 下载 |
