REDV 是纤连蛋白交替剪接的 III 型连接段 (IIICS) 区域的 CS5 位点内的最小活性序列。REDV 可以通过结合整合素 α4β1 介导与血浆纤连 IIICS 区域的粘附。REDV 可用于细胞粘附的研究。
编号：197485
CAS号：107978-83-6
单字母：H2N-REDV-OH
| 编号: | 197485 |
| 中文名称: | 多肽REDV |
| 英文名: | Arg-Glu-Asp-Val |
| CAS号: | 107978-83-6 |
| 单字母: | H2N-REDV-OH |
| 三字母: | H2N N端氨基 -Arg精氨酸 -Glu谷氨酸 -Asp天冬氨酸 -Val缬氨酸 -OHC端羧基 |
| 氨基酸个数: | 4 |
| 分子式: | C20H35N7O9 |
| 平均分子量: | 517.53 |
| 精确分子量: | 517.25 |
| 等电点(PI): | 6.46 |
| pH=7.0时的净电荷数: | -0.02 |
| 平均亲水性: | 1.875 |
| 疏水性值: | -1.83 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 层粘连蛋白(Laminins) |
REDV 是纤连蛋白交替剪接的 III 型连接段 (IIICS) 区域的 CS5 位点内的最小活性序列。REDV 可以通过结合整合素 α4β1 介导与血浆纤连 IIICS 区域的粘附。REDV 可用于细胞粘附的研究。
REDV is the minimal active sequence within the CS5 site of the alternatively spliced type III connecting segment (IIICS) region of fibronectin. REDV can mediate adhesion to the IIICS region of plasma fibronectin by binding the integrin alpha 4 beta 1(α4β1). REDV can be used for the research of cell adhesion[1].
Laminins are the protein network that is the foundation for most cells and organs. They are large trimeric proteins, also in the family of glycoproteins that contain an alpha chain, a beta chain and a gamma chain which are found in five, three and three genetic variants. As a family of glycoproteins, laminins are an integral part of the structural scaffolding in almost every tissue of an organism. This makes the laminin a vital part of the maintenance and survival of the tissues. Consequently, defective laminins cause muscular dystrophy, junctional epidermolysis bullosa and defects of the kidney a defect.
Recently, publications have shown that laminins can be used to culture cells that are difficult to culture on other substrates. These trimeric glycoproteins form a similar structure to a cross, giving it a structure that has the ability to bind to other cell membrane and extracellular molecules. The three shorter arms of the laminin are particularly efficient at binding to other laminin molecules, which allows them to form larger sheets. The long arm is capable of binding to cells, which then helps anchor organized tissue cells to the membrane. These laminins are an important and biologically active part of the basal lamina, influenincing cell differentiation, migration and adhesion.
S.P.Massia and J.A.Hubbell, J. Biol. Chem., 267, 14019(1992) : http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1629200
S P Massia, et al. Vascular endothelial cell adhesion and spreading promoted by the peptide REDV of the IIICS region of plasma fibronectin is mediated by integrin alpha 4 beta 1. J Biol Chem. 1992 Jul 15;267(20):14019-26
| 编号 | 名称 | CAS号 |
| 408257 | H2N-Gly-Gly-Gly-Arg-Glu-Asp-Val-COOH | |
| H2N-GGGREDV-OH | ||
| 413088 | 5TAMRA-Arg-Glu-Asp-Val-COOH | |
| 5Tamra-REDV-OH | ||
