Glypromate acetate是一种神经保护剂，是一种弱NMDA受体激动剂。
编号：138222
CAS号：32302-76-4
单字母：H2N-GPE-OH
| 编号: | 138222 |
| 中文名称: | Glypromate acetate |
| 英文名: | Glypromate acetate |
| CAS号: | 32302-76-4 |
| 单字母: | H2N-GPE-OH |
| 三字母: | H2N N端氨基 -Gly甘氨酸 -Pro脯氨酸 -Glu谷氨酸 -OHC端羧基 |
| 氨基酸个数: | 3 |
| 分子式: | C12H19N3O6 |
| 平均分子量: | 301.3 |
| 精确分子量: | 301.13 |
| 等电点(PI): | 6.36 |
| pH=7.0时的净电荷数: | -0.02 |
| 平均亲水性: | 3 |
| 疏水性值: | -1.83 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 激动剂多肽(Agonist Peptide) 三肽 糖尿病 |
这种IGF-I的N-末端三肽促进了乙酰胆碱的体外释放，其效力高出几百倍（10⁻¹⁰ - 10⁻⁶ M） 比完整的IGF-I（4/10⁻⁸ M） ，而缺乏三肽GPE的截短的IGF-I没有显示出任何显著的作用。这增加了GPE可能是IGF-I的活性位点的可能性尽管GPE的确切作用模式尚不清楚，但另一项研究表明，在脑HI损伤后，通过神经胶质细胞局部给予GPE具有神经保护作用。此外，全身给予GPE显示出更广泛的神经保护作用。因此，GPE可能代表IGF-1的中枢和全身抗凋亡作用的互补途径。
This N-terminal tripeptide of IGF-I facilitated the in vitro release of acetylcholine with a several hundredfold higher potency (10⁻¹⁰ - 10⁻⁶ M) than intact IGF-I (4 · 10⁻⁸ M), whereas truncated IGF-I lacking the tripeptide GPE, did not show any significant effect. This raises the possibility that GPE may be the active site of IGF-I. - Although the precise mode of action of GPE is still unknown, another study suggests that local administration of GPE is neuroprotective after brain HI injury via glial cells. In addition, systemic administration of GPE showed a more widespread neuroprotective effect. Therefore, GPE may represent a complementary pathway for central and systemic IGF-1's antiapoptotic effects.
Glypromate acetate是一种神经保护剂，是一种弱NMDA受体激动剂。
Glypromate acetate, a neuroprotective agent, is a weak NMDA receptor agonist.
| DOI | 名称 | |
|---|---|---|
| 10.1016/s0006-8993(01)03148-1 | Neuroprotective effects of the N-terminal tripeptide of IGF-1, glycine-proline-glutamate, in the immature rat brain after hypoxic-ischemic injury | 下载 |
| 10.1093/brain/awh156 | Simultaneous neuroprotection and blockade of inflammation reverses autoimmune encephalomyelitis | 下载 |
| 10.1097/01.wnr.0000127461.15985.07 | N-terminal tripeptide of IGF-1 improves functional deficits after 6-OHDA lesion in rats | 下载 |
| 10.1016/j.neuropharm.2004.07.002 | Neuroprotective effects of the N-terminal tripeptide of insulin-like growth factor-1, glycine-proline-glutamate (GPE) following intravenous infusion in hypoxic-ischemic adult rats | 下载 |
| 10.1111/j.1471-4159.2009.05980.x | The N-terminal tripeptide of insulin-like growth factor-I protects against beta-amyloid-induced somatostatin depletion by calcium and glycogen synthase kinase 3 beta modulation | 下载 |
| 10.1016/j.neulet.2009.03.003 | Delayed peripheral administration of the N-terminal tripeptide of IGF-1 (GPE) reduces brain damage following microsphere induced embolic damage in young adult and aged rats | 下载 |
| 10.2174/138955712798868995 | GPE and GPE analogues as promising neuroprotective agents | 下载 |
| 10.1016/j.neuron.2013.07.023 | Environmental enrichment rescues binocular matching of orientation preference in mice that have a precocious critical period | 下载 |
