有效的二肽血管紧张素 I 转换酶 (ACE) 抑制剂，IC₅₀ 0.008 mg/ml。应用 IT 降低自发性高血压大鼠的血压。
编号：175595
CAS号：38579-21-4
单字母：H2N-IY-OH
| 编号: | 175595 |
| 中文名称: | Ile-Tyr |
| 英文名: | Ile-Tyr |
| CAS号: | 38579-21-4 |
| 单字母: | H2N-IY-OH |
| 三字母: | H2N N端氨基 -Ile异亮氨酸 -Tyr酪氨酸 -OHC端羧基 |
| 氨基酸个数: | 2 |
| 分子式: | C15H22N2O4 |
| 平均分子量: | 294.35 |
| 精确分子量: | 294.16 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 1.97 |
| 平均亲水性: | -2.6 |
| 疏水性值: | 1.8 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | 1490 |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 二肽(Dipeptide) |
Potent dipeptide angiotensin I-converting enzyme (ACE) inhibitor, IC₅₀ 0.008 mg/ml. Application of IY reduced blood pressure in spontaneously hypertensive rats.
| DOI | 名称 | |
|---|---|---|
| 10.1021/ja0164327 | Spectroscopic properties of tyrosyl radicals in dipeptides | 下载 |
| 10.1016/j.foodchem.2016.12.039 | Identification and quantification of ACE-inhibiting peptides in enzymatic hydrolysates of plant proteins | 下载 |
| 10.1021/jf020482t | Angiotensin I-converting enzyme inhibitory peptides derived from wakame (Undaria pinnatifida) and their antihypertensive effect in spontaneously hypertensive rats | 下载 |
| 10.1248/bpb.27.189 | Antihypertensive effect of peptides from royal jelly in spontaneously hypertensive rats | 下载 |
| 10.1016/j.jnutbio.2003.11.004 | Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats | 下载 |
| 10.1021/jp054159f | Redox-active tyrosine residues in pentapeptides | 下载 |
| 10.1016/j.febslet.2009.12.008 | Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice | 下载 |
