| 编号: | 430273 |
| 中文名称: | 蛙皮激肽A Ranatachykinin A |
| 英文名: | Ranatachykinin A |
| CAS号: | 135690-47-0 |
| 单字母: | H2N-KPSPDRFYGLM-NH2 |
| 三字母: | H2N N端氨基 -Lys赖氨酸 -Pro脯氨酸 -Ser丝氨酸 -Pro脯氨酸 -Asp天冬氨酸 -Arg精氨酸 -Phe苯丙氨酸 -Tyr酪氨酸 -Gly甘氨酸 -Leu亮氨酸 -Met甲硫氨酸 -NH2C端酰胺化 |
| 氨基酸个数: | 11 |
| 分子式: | C60H92N16O15S1 |
| 平均分子量: | 1309.54 |
| 精确分子量: | 1308.66 |
| 等电点(PI): | 11.71 |
| pH=7.0时的净电荷数: | 2.97 |
| 平均亲水性: | 0.0375 |
| 疏水性值: | -0.79 |
| 消光系数: | 1490 |
| 标签: | 蛙皮素(Bombesin) |
Definition
Bombesin is a polypeptide that is found in the brain and gastrointestinal tract. Experimentally it has shown to cause the secretion of various substances (as gastrin and cholecystokinin) and to inhibit intestinal motility.
Discovery
Bombesin was isolated from the skin of the frog Bombina bonmina by Anastasi and team in 19711.
Classification
Bombesin-like peptides are grouped into three families - 1) Bombesin group, viz., bombesin and alytesin, 2) Ranatensin group viz., ranatensins, litorin, and Rohdei litorin, 3) Phyllolitorin group viz., Leu(8)- and Phe(8)-phyllolitorins.
Structural characteristics
Bombesin is a small peptide of 14 amino acids.
Mode of action
The biological activity of bombesin is mediated by binding to specific receptors viz., gastrin releasing peptide receptor (GRPR; called also BB2 receptor), neuromedin B receptor (NMBR; called also BB1 receptor) and bombesin receptor subtype 3 (BRS-3; called also BB3 receptor). Bombesin induce Ca2+ release from intracellular stores2.
Functions
Bombesin and bombesin-like factors show a wide spectrum of biological activities. It regulates the contraction of smooth muscle cells, induction of the secretion of neuropeptides and hormones. It is one of the most powerful substances showing anorexic effects in the hypothalamus. It induces the release of gastrin and cholecystokinin in the intestines and the pancreas. They also posses activities of cytokines.
References
1. Anastasi A, Erspamer V, Bucci M (1971). Isolation and structure of bombesin and alytesin, 2 analogous active peptides from the skin of the European amphibians Bombina and Alytes. Experientia., 27(2):166-167.
2. Wang JL, Kalyanaraman S, Vivo MD, Gautam N (1996). Bombesin and thrombin affect discrete pools of intracellular calcium through different G-proteins. Biochem J., 320:87-91.
