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iLRP1, iLRP, Immature Laminin Receptor Protein (58-66)

编号:434811

CAS号:

单字母:H2N-LLLAARAIV-OH

纠错
  • 编号:434811
    中文名称:iLRP1, iLRP, Immature Laminin Receptor Protein (58-66)
    英文名:iLRP1, iLRP, Immature Laminin Receptor Protein (58-66)
    单字母:H2N-LLLAARAIV-OH
    三字母:H2N

    N端氨基

    -Leu

    亮氨酸

    -Leu

    亮氨酸

    -Leu

    亮氨酸

    -Ala

    丙氨酸

    -Ala

    丙氨酸

    -Arg

    精氨酸

    -Ala

    丙氨酸

    -Ile

    异亮氨酸

    -Val

    缬氨酸

    -OH

    C端羧基

    氨基酸个数:9
    分子式:C44H82N12O10
    平均分子量:939.2
    精确分子量:938.63
    等电点(PI):-
    pH=7.0时的净电荷数:1.97
    平均亲水性:-0.8
    疏水性值:2.33
    消光系数:-
    标签:层粘连蛋白(Laminins)   

  • Laminins are the protein network that is the foundation for most cells and organs. They are large trimeric proteins, also in the family of glycoproteins that contain an alpha chain, a beta chain and a gamma chain which are found in five, three and three genetic variants. As a family of glycoproteins, laminins are an integral part of the structural scaffolding in almost every tissue of an organism. This makes the laminin a vital part of the maintenance and survival of the tissues. Consequently, defective laminins cause muscular dystrophy, junctional epidermolysis bullosa and defects of the kidney a defect.

    Recently, publications have shown that laminins can be used to culture cells that are difficult to culture on other substrates. These trimeric glycoproteins form a similar structure to a cross, giving it a structure that has the ability to bind to other cell membrane and extracellular molecules. The three shorter arms of the laminin are particularly efficient at binding to other laminin molecules, which allows them to form larger sheets. The long arm is capable of binding to cells, which then helps anchor organized tissue cells to the membrane. These laminins are an important and biologically active part of the basal lamina, influenincing cell differentiation, migration and adhesion.

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