Abarelix是一种合成的十肽，也是天然促性腺激素释放激素（GnRH）的拮抗剂。Abarelix直接竞争性结合并阻断垂体前叶的促性腺激素释放激素受体，从而抑制黄体生成素（LH）和卵泡刺激素（FSH）的分泌和释放。
编号：449724
CAS号：183552-38-7/547741-72-0
单字母：
| 编号: | 449724 |
| 中文名称: | 阿巴瑞克、Abarelix |
| 英文名: | Abarelix |
| CAS号: | 183552-38-7，默认;醋酸盐 |
| 三字母: | Ac-{d-2-Nal}-{d-4-Cpa}-{d-3-Pal}-S-{NMyr}-{d-Asp}-L-K(ipr)-P-{d-Ala}-NH2 |
| 分子式: | C72H95ClN14O14 |
| 平均分子量: | 1416.09 |
| 标签: | 现货多肽 拮抗剂相关肽(Antagonist Peptide) |
Abarelix是一种合成的十肽，也是天然促性腺激素释放激素（GnRH）的拮抗剂。Abarelix直接竞争性结合并阻断垂体前叶的促性腺激素释放激素受体，从而抑制黄体生成素（LH）和卵泡刺激素（FSH）的分泌和释放。在男性中，LH分泌的抑制会阻止睾酮的释放。因此，这可能会缓解与前列腺肥大或前列腺癌症相关的症状，因为维持前列腺生长需要睾酮。检查使用该制剂的活跃临床试验或封闭临床试验。
Abarelix is a synthetic decapeptide and antagonist of naturally occurring gonadotropin-releasing hormone (GnRH). Abarelix directly and competitively binds to and blocks the gonadotropin releasing hormone receptor in the anterior pituitary gland, thereby inhibiting the secretion and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone. As a result, this may relieve symptoms associated with prostate hypertrophy or prostate cancer, since testosterone is required to sustain prostate growth. Check for active clinical trials or closed clinical trials using this agent.
