编号:162614
CAS号:109770-29-8
三字母:H2N-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-OH
描 述:The remarkable histochemical features of Alzheimer's disease (AD) are plaques that contain cores of extracellular filaments, which have been identified as amyloid substance. The major component of this amyloid is the β-protein. The synthetic pept
编号:128066
CAS号:1802084-26-9
三字母:H2N-Asp-Ala-Glu-Phe-Arg-Arg-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
描 述:The English (H6R) mutation of β-amyloid peptides accelerates fibrillation without increasing protofibril formation. Ono et al. showed that the English and Tottori mutations alter Abeta assembly at its earliest stages, monomer folding and oligomerizat
编号:179290
CAS号:144410-00-4
三字母:H2N-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Gln-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
描 述:The Dutch mutation (E22Q) of amyloid β-peptide aggregates more readily than the wild-type peptide and the resulting fibrils show increased neurotoxicity. The mutant peptide E22Q induced apoptosis of cerebral endothelial cells at a concentration of 25
编号:171768
CAS号:131580-10-4
三字母:H2N-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-OH
描 述:The Cu²⁺ complex of this soluble amyloid β-protein fragment showed significant oxidative activities toward the catechol-like substrate 1,2,3-trihydroxylbenzene (pyrogallol) and plasmid DNA cleavage. The N-terminal Aβ fragments Aβ1-14,
编号:147071
CAS号:1802086-23-2
三字母:H2N-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Gly-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
描 述:The arctic mutant of amyloid β peptide 1-42, in which Glu²² is substituted by Gly, is distinctly more amyloidogenic than the wild-type Aβ 1-42.
编号:122490
CAS号:315229-44-8
三字母:H2N-Phe-Leu-His-Gln-Glu-Arg-Met-Asp-Val-Cys-Glu-Thr-His-Leu-His-Trp-His-Thr-Val-Ala-Lys-OH
描 述:The APP fragment FLHQERMDVCETHLHWHTVAK comprises a copper(II)-binding site. Binding of Cu(II) to the peptide induced oxidation of the cysteine and intermolecular dimerization of the peptide. The reduction of Cu(II) to Cu(I) by APP may enhance the producti
编号:197812
CAS号:134500-80-4
三字母:H2N-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-Thr-OH
描 述:The amyloid β-protein is a 39- to 43-amino acid polypeptide that is the primary constituent of senile plaques and cerebrovascular deposits in Alzheimer's disease and Down's syndrome. Additionally it acts as an inhibitor of the ubiquitin-depen
编号:151082
CAS号:154040-19-4
三字母:H2N-Glu-Gln-Val-Thr-Asn-Val-Gly-Gly-Ala-Val-Val-Thr-Gly-Val-Thr-Ala-Val-Ala-Gln-Lys-Thr-Val-Glu-Gly-Ala-Gly-Ser-Ile-Ala-Ala-Ala-Thr-Gly-Phe-Val-OH
描 述:The 35 amino acid peptide NAC (α-synuclein (61-95)) has originally been isolated from the insoluble core of Alzheimer's disease (AD) amyloid plaque. The sequence corresponds to a fragment of a 140 amino acid precursor known as NACP or α-sy
编号:174955
CAS号:150234-52-9
三字母:H2N-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-OH
描 述:SEVNLDAEF 对应于在患有早发性阿尔茨海默病的瑞典家族中发现的淀粉样前体蛋白 (APP) 的突变连接序列,因此被称为“瑞典”突变 (K670N/M671L)。该肽已用于测定组织蛋白酶 G 和胰凝乳蛋白酶对亮氨酸-天冬氨酸的裂解,而组织蛋白酶 B、D 和 L 均未产生任何产物。
编号:159953
CAS号:330936-70-4
三字母:H2N-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH
描 述:S14G-Humanin (HNG) 是一种比天然humanin 更有效的神经保护因子。在中年 APPswe/PS1dE9 小鼠中,突变肽改善了认知缺陷并减少了淀粉样蛋白病理。S14G-Humanin 抑制 Aβ 1-42 原纤维的形成,分解预先形成的原纤维,并在体外防止 Abeta 诱导的细胞毒性。